Apolipoprotein B/A1 Ratio

Normal range: 0 – 0.77 (lower is better)

The ApoB/ApoA1 ratio captures the balance between atherogenic (harmful) and cardioprotective particles in a single number. Several large studies have found it to be one of the strongest predictors of cardiovascular risk, often outperforming LDL or the standard cholesterol/HDL ratio. A lower ratio means your protective particles are winning the battle against the harmful ones.

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What can cause high ApoB/A1?

A normal ApoB/A1 is 0 – 0.77. Lower is better.

A high ApoB/A1 ratio means too many harmful particles relative to protective ones. The same factors that raise ApoB (poor diet, insulin resistance, genetics) or lower ApoA1 (sedentary lifestyle, smoking, obesity) push this ratio up. Addressing either side improves the balance.

Exercise is uniquely effective here because it both lowers ApoB and raises ApoA1, improving the ratio from both directions. Reducing saturated fat, quitting smoking, losing excess weight, and replacing unhealthy fats with unsaturated fats all help. Statins improve the ratio primarily by lowering the ApoB side.

Biomarkers related to ApoB/A1

ApoB/A1 is most highly correlated with Apolipoprotein B and Non-HDL Cholesterol. Here are the top biomarkers correlated with ApoB/A1, based on 500,000 tests done by Empirical Health.

The percentage shows how strongly two biomarkers move together. A higher number means the relationship is stronger. Green = rises and falls together. Orange = one rises as the other falls.

ApoB/A1 test cost

You can test your ApoB/A1 for $190 as part of Empirical's comprehensive health panel, which includes 100 biomarkers.

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Where to test ApoB/A1

You can measure your ApoB/A1 for at 2,200+ testing locations across the US. Click below and enter your zip code to browse locations near you.

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