Know your Chloride. Know your health.
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Normal range: 96 – 106 mmol/L (higher is better)
Chloride is an electrolyte that works hand-in-hand with sodium to maintain fluid balance and blood pH. It also helps form stomach acid. Chloride usually moves in parallel with sodium, so abnormal chloride levels often reflect the same underlying issue driving a sodium change. When chloride moves independently of sodium, it points to an acid-base problem.
A normal Chloride is 96 – 106 mmol/L. Higher is better.
Low chloride is most commonly caused by prolonged vomiting (which depletes stomach acid), diuretic use, or metabolic alkalosis. High chloride typically accompanies dehydration, excessive saline infusion, kidney disease, or metabolic acidosis (such as from chronic diarrhea).
Diuretics are the most common medication cause. Loop diuretics (furosemide) and thiazides tend to lower chloride, while acetazolamide can raise it. Chronic bicarbonate or antacid use can also shift chloride levels.
For most people, chloride stays in range as long as sodium does. Staying hydrated and being aware of medication effects are the main considerations. There are no specific dietary interventions targeted at chloride alone.
Chloride is most highly correlated with Sodium and Carbon Dioxide. Here are the top biomarkers correlated with Chloride, based on 500,000 tests done by Empirical Health.
The percentage shows how strongly two biomarkers move together. A higher number means the relationship is stronger. Green = rises and falls together. Orange = one rises as the other falls.
You can test your Chloride for $190 as part of Empirical's comprehensive health panel, which includes 100 biomarkers.
You can measure your Chloride for at 2,200+ testing locations across the US. Click below and enter your zip code to browse locations near you.
Test your Chloride and 100+ other biomarkers in a single blood draw.