Normal range: 7 – 55 U/L (lower is better)
ALT is an enzyme concentrated in your liver cells. When those cells are damaged or inflamed, ALT leaks into the bloodstream, so a blood test can pick it up. It is the most specific marker of liver injury. Elevated ALT is commonly seen in fatty liver disease, viral hepatitis, alcohol use, and medication-related liver stress. Even mildly elevated ALT over time is associated with increased risk of liver disease progression.
A normal ALT is 7 – 55 U/L. Lower is better.
Non-alcoholic fatty liver disease (NAFLD) is now the most common cause of elevated ALT, driven by obesity and insulin resistance. Losing even 5-10% of body weight can significantly lower ALT in people with fatty liver. Alcohol use, viral hepatitis (B and C), and medications (especially acetaminophen, statins, and certain antibiotics) are other frequent causes.
Intense exercise can temporarily spike ALT for 24-48 hours. Herbal supplements (especially kava, green tea extract, and comfrey) are an underappreciated cause of liver injury and elevated ALT.
Lifestyle changes are the frontline treatment for elevated ALT. Cutting back on alcohol, losing excess weight, exercising regularly, and reducing sugar intake can all bring levels down. If you take regular medications, your doctor may monitor ALT periodically to catch liver stress early.
ALT is most highly correlated with AST and Ferritin. Here are the top biomarkers correlated with ALT, based on 500,000 tests done by Empirical Health.
The percentage shows how strongly two biomarkers move together. A higher number means the relationship is stronger. Green = rises and falls together. Orange = one rises as the other falls.
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