Globulin

Normal range: 2 – 3.5 g/dL (higher is better)

A globulin blood test measures a group of proteins that includes your immune antibodies and transport proteins. Think of globulins as your immune system's protein signature. When your body is fighting infection or dealing with chronic inflammation, globulin levels tend to rise. When your immune system is weakened, they drop. Globulin is most useful when read alongside albumin.

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What can cause low Globulin?

A normal Globulin is 2 – 3.5 g/dL. Higher is better.

High globulin is more common than low. Chronic infections (hepatitis, HIV), autoimmune conditions (lupus, rheumatoid arthritis), and plasma cell disorders (multiple myeloma) are the main causes. Even mild chronic inflammation can nudge globulin upward over time.

Low globulin may indicate an immune deficiency, impaired antibody production, or protein loss through the kidneys. Corticosteroids and immunosuppressant medications can lower globulin by dampening immune activity. Malnutrition and liver disease reduce production as well.

Lifestyle changes that reduce chronic inflammation, such as regular exercise, a balanced diet, and maintaining a healthy weight, can help normalize elevated globulin. If globulin is low, working with your doctor to identify and treat the underlying cause is the best approach.

Biomarkers related to Globulin

Globulin is most highly correlated with Total Protein and Albumin. Here are the top biomarkers correlated with Globulin, based on 500,000 tests done by Empirical Health.

The percentage shows how strongly two biomarkers move together. A higher number means the relationship is stronger. Green = rises and falls together. Orange = one rises as the other falls.

Globulin test cost

You can test your Globulin for $190 as part of Empirical's comprehensive health panel, which includes 100 biomarkers.

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Where to test Globulin

You can measure your Globulin for at 2,200+ testing locations across the US. Click below and enter your zip code to browse locations near you.

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